Custom Synthesis

Aptiance's experts are highly specialized in the design and complex multistep synthesis of organic/heterocyclic/steroidal molecules and their intermediates and can assist clients, with all phases of the discovery-development-clinical process, in the pharmaceutical, drug discovery, agrochemical and biotechnology industries, government labs and universities.

We have world class skills and extensive experience necessary to provide a wide range services from medicinal chemistry support up through process development/scale-up, supply of pharmacology and of preclinical materials.

We can rapidly synthesize custom organic compounds at the mg and gram scales, to accelerate your R&D and preclinical development programs. When project requirements exceed our in-house capacity, we can provide vendor sourcing and technology transfer to other cGMP/non-cGMP manufacturers.

For custom synthesis the customer provides literature methods or their own synthesis route in which all details (reaction times, solvents, temperatures, analytical data, purification methods, yields, etc.) are included. If you have no technical information about the product that you want, we can still synthesize the material on the contract basis and on a very reasonable price.

We specialize in the following Custom Organic Synthesis Services:
  • Hetrocyclic Organic Compounds (design, synthesis and optimization)
  • Complex Organic Compounds (design, synthesis and optimization).
  • Multistep Synthesis of Steroidal Compound (optically pure, design, synthesis and optimization).
  • Custom Synthesis of Chemical Intermediates and Building Blocks
  • Custom Synthesis of internal standards for pharmacokinetics
  • Custom synthesis of metabolites.
  • Custom synthesis of Active compounds for in-vitro, and pre-clinical research
  • Process Development for Large Scale Production and Technology Transfer
  • Analytical Chemistry (identify, purity, composition in the product mixture or isolated technical material)
  • Analytical Separation and Isolation of Pure Compound (analytical or semi-prep chromatography)
  • Analytical Purification of Compounds in small amounts.
Contract Custom Synthesis

Contract Custom Synthesis is carried out in a completely confidential manner. After a mutual agreement, a synthetic program can be signed on a contract basis where we will conduct literature search, and find out the best possible route of synthesis, do some preliminary experiments to determine feasibility and good yield for the targeted compound.
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